There are several existing treatments for alopecia areata but none of them offers stable and satisfactory results. Sulfasalazine for Alopecia Areata. In one study, 26 patients with recalcitrant or severe alopecia areata (>40% scalp hair loss) received treatment with sulfasalazine 500 mg bid for the first month, then 1 g bid for the second month, and 1.5 g bid for a further three months. Reduced me to 1000 mg nonetheless. I don't fancy getting chronic diarrhoea or vomiting either. People with rheumatoid arthritis (RA) may experience hair loss as a symptom of the disease or due to medication that they are taking. Switched to Sulfasalazine 7 months ago on 2000mg. Docs didnât believe it was sulfa, just stress. Promising results have been published in the past with the use of sulfasalazine in alopecia areata. 3 ⦠Forced to stop Methotrexate at week 8 due to hair loss. A deficiency in folic acid can cause thinning and loss of hair. Sulfasalazine oral tablet is a prescription medication that's used to treat rheumatoid arthritis, juvenile rheumatoid arthritis, and ulcerative colitis. Subject: Re: Sulfasalazine OR Methotrexate? typed in Sulfasalazine didn't show up. Alopecia areata is an autoimmune disease mediated by T lymphocytes that results in patchy or confluent hair loss involving the scalp and body. Last fall, I started on 2000 mg sulfasalazine. Iâve never experienced anything like this, am relatively young, ethnic so have lots of hair to come out (and oh it did). 1 The pathologic process involves a perifollicular T-cell infiltrate that causes a cytokine-mediated premature conversion of affected hairs from anagen to telogen 2 and abnormal keratinization with resultant abnormalities of the hair shaft. Indirectly, the answer is yes. Switched to Sulfasalazine and the hair loss stopped, but in the last couple months started losing hair again and have a bald patch on the back of my head. where the heck do you buy this stuff on alldaychemist? Hair Loss Study Abstract Sulfasalazine is used as a therapy for various autoimmune conditions, including psoriasis; its effectiveness is presumed to be the result of its immunomodulatory effects. 4 months on 2000mg per day but no improvement but also no side effects. At 5 months I developed plantar fasciitis, severe fatigue, apathy, low mood and stiffness throughout my whole body. I'm 25 and this is NOT a side effect of sulfasalazine, so I guess this is just what many uc sufferers have to ⦠Major hair loss started a few months after - I mean, major. I was told it was the PsA. Sulfasalazine can have an affect on folic acid levels causing a deficiency. 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